Related Experiment Video
Updated: Jan 11, 2026
08:48
Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
Published on: March 19, 2019
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Candida
Emily M Eichenberger1, Stephanie Pouch1
1Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA.
JHLT Open
|November 11, 2025
Summary
Invasive candidiasis poses a severe threat to thoracic organ transplant recipients. This review covers its epidemiology, diagnosis, and management, including emerging resistant strains.
Area of Science:
- Infectious Diseases
- Transplantation Medicine
- Mycology
Background:
- Invasive candidiasis is a critical, life-threatening condition in thoracic organ transplant recipients.
- Candida species can rapidly shift from commensal colonization to pathogenic invasion in these immunocompromised individuals.
Purpose of the Study:
- To review the epidemiology, clinical presentation, diagnosis, and management of invasive candidiasis in thoracic organ transplant recipients.
- To highlight the diverse manifestations and challenges associated with these infections.
Main Methods:
- Literature review focusing on invasive candidiasis in thoracic organ transplant recipients.
- Analysis of current therapeutic strategies and emerging resistance patterns.
Main Results:
- Invasive candidiasis presents with varied manifestations, including candidemia, endobronchial/anastomotic infections, pleural infections, mediastinitis, and sternal osteomyelitis.
- Management involves addressing diverse clinical scenarios and the growing issue of antifungal resistance.
Conclusions:
- Effective management of invasive candidiasis in thoracic organ transplant recipients requires a comprehensive understanding of its epidemiology and clinical spectrum.
- Addressing the threat of resistant Candida species is crucial for improving patient outcomes.
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