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Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
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Candida.

Emily M Eichenberger1, Stephanie Pouch1

  • 1Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA.

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Summary
This summary is machine-generated.

Invasive candidiasis poses a severe threat to thoracic organ transplant recipients. This review covers its epidemiology, diagnosis, and management, including emerging resistant strains.

Keywords:
CandidaCandidemiaCandidiasisHeart transplantInvasive candidiasisLung transplant

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Area of Science:

  • Infectious Diseases
  • Transplantation Medicine
  • Mycology

Background:

  • Invasive candidiasis is a critical, life-threatening condition in thoracic organ transplant recipients.
  • Candida species can rapidly shift from commensal colonization to pathogenic invasion in these immunocompromised individuals.

Purpose of the Study:

  • To review the epidemiology, clinical presentation, diagnosis, and management of invasive candidiasis in thoracic organ transplant recipients.
  • To highlight the diverse manifestations and challenges associated with these infections.

Main Methods:

  • Literature review focusing on invasive candidiasis in thoracic organ transplant recipients.
  • Analysis of current therapeutic strategies and emerging resistance patterns.

Main Results:

  • Invasive candidiasis presents with varied manifestations, including candidemia, endobronchial/anastomotic infections, pleural infections, mediastinitis, and sternal osteomyelitis.
  • Management involves addressing diverse clinical scenarios and the growing issue of antifungal resistance.

Conclusions:

  • Effective management of invasive candidiasis in thoracic organ transplant recipients requires a comprehensive understanding of its epidemiology and clinical spectrum.
  • Addressing the threat of resistant Candida species is crucial for improving patient outcomes.