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Updated: Jan 11, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Copper-catalyzed cross-coupling reaction of epoxides with allyl boron ester
Xiao-Yu Lu1, Jun-Long Zhang1, Hao-Yu Dong1
1School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou, 239000, China. xiaoyulu@mail.ustc.edu.cn.
Abstract:
Herein, a copper-catalyzed ring-opening cross-coupling reaction of epoxides with allylboronates for the synthesis of γ-alkenyl alcohols is reported. This protocol demonstrates broad functional group compatibility, facilitating the production of secondary and tertiary alcohols from both monosubstituted and 1,1-disubstituted epoxides. Mechanistic studies indicate that the reaction proceeds via an iodide-mediated ring-opening pathway. Additionally, gram-scale synthesis and subsequent derivatizations confirm the practical utility of this method for generating intermediates in pharmaceuticals and natural products.
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