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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Magnesium supplementation for migraine prophylaxis.

Juan Pablo Rodriguez¹, Estefania Quarteroni¹, Lucia B Varela¹

¹Cochrane Associate Centre, Universidad Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

The Cochrane Database of Systematic Reviews

|November 11, 2025

Summary

This summary is machine-generated.

Magnesium supplementation may help prevent migraines in children and adults. This review assesses its benefits and harms compared to standard treatments or placebo, considering various demographic groups.

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Area of Science:

Neurology
Nutritional Science
Evidence-Based Medicine

Background:

Migraine is a common neurological disorder affecting millions globally.
Current pharmacological treatments for migraine have limitations and potential side effects.
Magnesium is a mineral involved in numerous physiological processes, including neurotransmission and vascular tone, suggesting a potential role in migraine prevention.

Purpose of the Study:

To systematically evaluate the efficacy and safety of magnesium supplementation for preventing episodic and chronic migraine in pediatric and adult populations.
To compare magnesium supplementation against placebo or usual pharmacological care.
To explore potential differential effects of magnesium supplementation based on equity-related factors like age, sex, and socioeconomic status.

Main Methods:

This study is a protocol for a Cochrane Review, employing rigorous systematic review methodology.
The review will synthesize evidence from randomized controlled trials (RCTs) investigating magnesium supplementation for migraine prevention.
Data extraction and quality assessment will follow established Cochrane guidelines.

Main Results:

The review is currently a protocol; results are pending completion of the systematic review process.
Anticipated results will quantify the benefits and harms of magnesium supplementation for migraine prevention.
Analysis will also investigate heterogeneity across different population subgroups.

Conclusions:

The findings will inform clinical practice regarding the use of magnesium for migraine prevention.
This review aims to provide high-quality evidence to guide healthcare providers and patients.
Understanding effects across diverse groups will promote equitable migraine management strategies.