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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Updated: Jan 11, 2026

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
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Crizotinib-Associated Uveitis and Scleritis with Abscess Formation.

Je Moon Yoon1, Seung Wan Nam2, Min Ji Kim3

  • 1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Ocular Immunology and Inflammation
|November 11, 2025
PubMed
Summary
This summary is machine-generated.

Crizotinib treatment for lung cancer can cause severe eye inflammation, including uveitis and scleritis with abscesses. Switching to another tyrosine kinase inhibitor resolved this vision-threatening condition in two patients.

Area of Science:

  • Ophthalmology
  • Oncology
  • Pharmacology

Background:

  • Crizotinib is a tyrosine kinase inhibitor used to treat anaplastic lymphoma kinase-positive lung cancer.
Keywords:
Aseptic abscesscrizotinibscleritisuveitis

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  • Ocular side effects of tyrosine kinase inhibitors are increasingly recognized.
  • Uveitis and scleritis are inflammatory conditions affecting the eye.