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[Progress on predictive biomarkers for exudation in polypoidal choroidal vasculopathy].
1Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China.
Polypoidal choroidal vasculopathy (PCV) lesion activity can be assessed using multimodal retinal imaging. Understanding these activity markers aids in personalized treatment and follow-up for neovascular age-related macular degeneration (nAMD).
Area of Science:
- Ophthalmology
- Medical Imaging
- Genetics
Background:
- Polypoidal choroidal vasculopathy (PCV) is a significant subtype of neovascular age-related macular degeneration (nAMD), particularly prevalent in Asian populations.
- PCV lesions exhibit variable activity levels during clinical follow-up, necessitating accurate assessment methods.
Purpose of the Study:
- To review recent advancements in understanding PCV lesion activity using multimodal retinal imaging.
- To explore the clinical impact and future prospects of assessing PCV lesion activity for personalized patient management.
Main Methods:
- Analysis of multimodal retinal imaging techniques for PCV lesion assessment.
- Identification of biological markers (vascular networks, polypoidal lesions, choroidal features) and patient factors (demographics, genetics) indicative of lesion activity.
Main Results:
- Multimodal imaging effectively assesses PCV lesion activity.
- Abnormal branching vascular networks, polypoidal lesions, and choroidal features are key predictors of lesion activity.
- Demographic and genetic factors may also influence PCV lesion activity.
Conclusions:
- Multimodal retinal imaging provides crucial insights into PCV lesion activity.
- Understanding lesion activity characteristics is vital for tailoring treatment and follow-up plans in clinical ophthalmic practice.
- This knowledge supports personalized management strategies for PCV patients.
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