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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

736
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Gut microbiome in IBD: past, present and the future.

Jingwan Zhang1, Joyce Wing Yan Mak1, Siew C Ng2,3

  • 1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.

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|November 11, 2025
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Inflammatory bowel disease (IBD) is linked to gut microbiome changes. Research explores how microbes, genetics, and environment impact IBD, seeking new diagnostic and treatment strategies.

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IBDINFLAMMATORY BOWEL DISEASEMICROBIOME

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Area of Science:

  • Gastroenterology and Microbiology
  • Host-Microbiome Interactions
  • Inflammatory Bowel Disease (IBD) Research

Background:

  • IBD is a growing global health concern.
  • Gut microbiome alterations (bacteria, fungi, viruses) are implicated in IBD pathogenesis.
  • Understanding host-microbiota interactions is crucial for IBD management.

Purpose of the Study:

  • To review the evolution of microbiome research in IBD.
  • To highlight the role of genetic and environmental factors on the gut microbiota.
  • To explore cross-kingdom microbiome contributions and therapeutic strategies for IBD.

Main Methods:

  • Review of recent advances in sequencing technologies.
  • Integration of multi-omics data.
  • Analysis of experimental approaches in host-microbiota research.

Main Results:

  • Microbiota and their metabolites significantly contribute to IBD development.
  • Genetic and environmental factors influence the gut microbiota composition.
  • Cross-kingdom interactions within the microbiome play a key role in disease.

Conclusions:

  • Microbiome-based approaches offer potential for IBD diagnosis, monitoring, prevention, and treatment.
  • Further research into host-microbiota interactions is vital for advancing IBD care.
  • Targeting the gut microbiome presents a promising therapeutic avenue for IBD.