Lumbar Extradural Extraskeletal Ewing Sarcoma with Psoas Denervation: A Case Report.
1Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
The American Journal of Case Reports
|November 12, 2025
Summary
Extraskeletal Ewing sarcoma rarely occurs in the spine's extradural region. This case highlights an extremely rare instance of spinal extraskeletal Ewing sarcoma causing psoas muscle denervation due to compression.
Area of Science:
- Oncology
- Neurology
- Radiology
Background:
- Extraskeletal Ewing sarcoma (EES) is a rare tumor, with spinal extradural involvement being uncommon.
- Psoas muscle denervation is typically caused by nerve injury or aging, but spinal EES is an extremely rare cause.
- This report details a unique case of spinal EES leading to psoas denervation.
Purpose of the Study:
- To report an extremely rare case of spinal extradural extraskeletal Ewing sarcoma causing psoas denervation.
- To discuss the diagnostic and clinical implications of this rare presentation.
Main Methods:
- A case report of a 38-year-old male patient with back pain.
- Diagnostic imaging included MRI of the thoracolumbar spine and CT of the chest.
- Tumor biopsy with histopathological and immunohistochemical analysis (CD99, NKX2.2) confirmed the diagnosis.
Main Results:
- MRI revealed an extradural mass at L1-L2 compressing the psoas muscle, causing edema.
- Histopathology confirmed extraskeletal Ewing sarcoma with characteristic small blue round cells.
- The tumor showed no response to chemotherapy, and the patient died 12 months post-presentation.
Conclusions:
- Spinal extradural EES is rare, and its association with psoas denervation is exceptionally uncommon.
- Early diagnosis and understanding of EES presentation are crucial for patient management.
- This case underscores the diverse and rare clinical manifestations of Ewing sarcoma family tumors.
