Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Aerosol therapy during noninvasive ventilation (NIV) and nasal high-flow therapy (HFT): current technology and consensus-based recommendations.

Pneumologie (Stuttgart, Germany)·2026

Same author

Ultrasound-facilitated catheter-directed thrombolysis is associated with improved survival and reduces hospital stay in acute pulmonary embolism: a propensity score-matched analysis.

Journal of thoracic disease·2026

Same author

Outcomes of EKOS (Ultrasound-Assisted Thrombolysis) for Intermediate-High-Risk Pulmonary Embolism: A PERT-Guided Cohort Study.

Interdisciplinary cardiovascular and thoracic surgery·2026

Same author

Characterization of post-COVID syndrome by self-perceived symptom severity stratified by infection wave: beyond COVID, a prospective, multicenter cohort study in Germany.

Infection·2026

Same author

Modelling inflammatory endothelial dysfunction: a human in vitro platform for translational research.

Frontiers in bioengineering and biotechnology·2026

Same author

[Strategies to Improve Deficient Communication in Chronic Progressive Diseases in outpatient and hospital care - Practical Approaches for COPD and Idiopathic Pulmonary Fibrosis].

Deutsche medizinische Wochenschrift (1946)·2026

Same journal

The epidemiological burden and societal cost of 14 respiratory conditions in the World Health Organization European region: systematic evidence map and economic analysis.

ERJ open research·2026

Same journal

Menthol inhalation relieves dyspnoea through the brain.

ERJ open research·2026

Same journal

Understanding the perceptions and experiences of adults with early-onset neuromuscular disorders using noninvasive ventilation in making healthcare decisions.

ERJ open research·2026

Same journal

Exploring glucocorticoid receptor signalling in lymphangioleiomyomatosis.

ERJ open research·2026

Same journal

Senescence intensifies bleomycin-induced injury in idiopathic pulmonary fibrosis lung epithelial cells.

ERJ open research·2026

Same journal

Absolute and relative intensity of physical activity after lung cancer surgery.

ERJ open research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 11, 2026

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit

Published on: September 6, 2024

Differences in severity grading of lung hyperinflation using GLI versus ECSC reference values.

Lora Wahab¹, Wolfram Windisch^2,3, Carl-Peter Criée⁴

¹Department of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, Aachen, Germany.

ERJ Open Research

|November 12, 2025

Summary

This summary is machine-generated.

The Global Lung Initiative (GLI) 2021 equations significantly alter lung hyperinflation grading. This study shows GLI 2021 increases severe hyperinflation detection, requiring a review of current severity scales.

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Measurement of the Pressure-volume Curve in Mouse Lungs

Measurement of the Pressure-volume Curve in Mouse Lungs

Published on: January 27, 2015

Related Experiment Videos

Last Updated: Jan 11, 2026

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit

Published on: September 6, 2024

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Measurement of the Pressure-volume Curve in Mouse Lungs

Measurement of the Pressure-volume Curve in Mouse Lungs

Published on: January 27, 2015

Area of Science:

Pulmonary Function Testing
Respiratory Medicine
Clinical Diagnostics

Background:

The Global Lung Initiative (GLI) network updated lung function reference equations in 2021.
These new equations established revised normal ranges for lung hyperinflation indices.
This impacts the classification and severity grading of lung hyperinflation.

Purpose of the Study:

To evaluate the impact of GLI 2021 reference equations on lung hyperinflation detection.
To assess changes in the distribution of lung hyperinflation severity grading.
To compare GLI 2021 findings with previous European Coal and Steel Community (ECSC) equations.

Main Methods:

Analysis of 12,535 body plethysmography recordings (2013-2023).
Calculation of z-scores for residual volume (RV), total lung capacity (TLC), and RV/TLC using GLI 2021 and ECSC equations.
Assessment of lung hyperinflation severity distribution based on % predicted RV/TLC and z-scores.

Main Results:

Severe lung hyperinflation was detected more frequently with GLI 2021 equations (27%) compared to ECSC (8.8%).
Mild lung hyperinflation was less frequent with GLI 2021 (7%) versus ECSC (21%).
Grading using GLI 2021 z-scores showed similar distribution to ECSC % predicted cut-offs.

Conclusions:

GLI 2021 reference equations significantly alter lung hyperinflation grading, particularly when using % predicted cut-offs.
A review of the lung hyperinflation severity scale is necessary for accurate classification with GLI 2021.
Clinical practice should consider these changes for consistent and reliable diagnosis.