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Customizable Task-Agnostic Exoskeleton Control for Targeted Neuromuscular Assistance: Case Series
Nikhil V Divekar1, Alicia Baxter2, Robert D Gregg1
1Department of RoboticsUniversity of Michigan Ann Arbor MI 48109 USA.
IEEE Open Journal of Engineering in Medicine and Biology
|November 12, 2025
Summary
This study customized a knee exoskeleton controller for individuals with severe mobility impairments, like post-polio syndrome (PPS) and multiple sclerosis (MS). The tailored approach successfully improved key mobility deficits in both participants.
Area of Science:
- Biomedical Engineering
- Rehabilitation Robotics
- Neuroscience
Background:
- Individuals with severe neuromuscular deficits often face significant mobility challenges.
- Existing assistive devices may not adequately address the unique needs of highly impaired individuals.
- Task-agnostic controllers offer potential for versatile exoskeleton assistance.
Purpose of the Study:
- To customize and validate a task-agnostic bilateral knee exoskeleton controller.
- To target primary neuromuscular deficits in individuals with post-polio syndrome (PPS) and multiple sclerosis (MS).
- To develop a user-friendly interface for gait parameter tuning.
Main Methods:
- Leveraged biomechanics-based controller structure for specialized modifications.
- Targeted primary gait deficits in participants with PPS and MS.
- Utilized an Android interface for clinician-friendly parameter tuning.
Main Results:
- Customized assistance improved primary mobility deficits for both participants.
- Reduced five-times-sit-to-stand time for the PPS participant (18.9s to 11.8s).
- Restored normative knee flexion and reduced circumduction in the MS participant.
Conclusions:
- A biomechanics-based, task-agnostic exoskeleton controller can be effectively customized.
- Specialized modifications and interface-based tuning enable targeted improvements.
- This approach addresses the unique mobility deficits of highly impaired individuals.
Keywords:
Exoskeletonsbioinspired controlmultiple sclerosis (MS)post-polio syndrome (PPS)user interfaces
