Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

1.2K
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clopidogrel versus ticagrelor in dual antiplatelet therapy for flow diversion of unruptured intracranial aneurysms: analysis of the Neurovascular Quality Initiative-Quality Outcomes Database (NVQI-QOD) Cerebral Aneurysm Registry.

Journal of neurointerventional surgery·2026
Same author

Factors Associated With the Rising Trend in Self-Reported Cognitive Disability Among U.S. Adults Aged 18-39 From 2013-2024.

Annals of clinical and translational neurology·2026
Same author

Acquired genetic and cell-state changes in IDH-mutant glioma progression.

Nature·2026
Same author

Racial and Socioeconomic Disparities in Blood Pressure Control Before and After Intracerebral Hemorrhage.

medRxiv : the preprint server for health sciences·2026
Same author

Multiomics Profiling Supports Cathepsin B as a Protective Factor in Cerebral Small Vessel Disease.

Research square·2026
Same author

Human claustrum neurons encode uncertainty and prediction errors during aversive learning.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: May 1, 2026

A Murine Model of Subarachnoid Hemorrhage
07:40

A Murine Model of Subarachnoid Hemorrhage

Published on: November 21, 2013

20.4K

SLAMF1 as a Risk Biomarker for Nontraumatic SAH: Evidence From a Multiomics Study.

Daniela Renedo1, Andrew Koo1, Nanthiya Sujijantarat1

  • 1Department of Neurosurgery (D.R., A.B.K., N.S., R.H., C.C.M.), Yale University School of Medicine, New Haven, CT.

Stroke
|November 12, 2025
PubMed
Summary
This summary is machine-generated.

Subarachnoid hemorrhage (SAH) risk may be predicted by signaling lymphocytic activation molecule family member 1 (SLAMF1). This protein, involved in immune responses, shows potential as a biomarker for SAH, aiding in risk stratification and prevention.

Keywords:
Mendelian randomization analysisbiological specimen banksproteomicssignaling lymphocytic activation molecule family member 1subarachnoid hemorrhage

More Related Videos

The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects
09:00

The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects

Published on: October 2, 2014

14.0K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K

Related Experiment Videos

Last Updated: May 1, 2026

A Murine Model of Subarachnoid Hemorrhage
07:40

A Murine Model of Subarachnoid Hemorrhage

Published on: November 21, 2013

20.4K
The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects
09:00

The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects

Published on: October 2, 2014

14.0K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K

Area of Science:

  • Cerebrovascular disease research
  • Proteomics and biomarker discovery
  • Immunology and inflammation

Background:

  • Subarachnoid hemorrhage (SAH) is a severe cerebrovascular event with limited predictive biomarkers.
  • Accurate prediction of aneurysm rupture risk is crucial for improving patient outcomes and identifying therapeutic targets.

Purpose of the Study:

  • To identify protein markers associated with SAH risk using proteomic and genetic analyses in the UK Biobank.
  • To explore the potential of identified proteins as biomarkers for SAH risk stratification and therapeutic development.

Main Methods:

  • Longitudinal Cox proportional hazards analyses of 2923 proteins and incident SAH in 52,916 UK Biobank participants.
  • Mendelian randomization to confirm protein-SAH associations using cis-protein quantitative trait loci.
  • Single-cell transcriptomic analysis to examine cellular expression profiles of significant proteins.

Main Results:

  • Signaling lymphocytic activation molecule family member 1 (SLAMF1) and Ninjurin 1 (NINJ1) were significantly associated with increased SAH risk.
  • Mendelian randomization confirmed the association for SLAMF1, with its directionality supported by reverse analysis.
  • SLAMF1 demonstrated high expression in specific immune cells, suggesting a potential immunologic role in SAH.

Conclusions:

  • SLAMF1 is identified as a protein associated with elevated SAH risk.
  • SLAMF1's role in immune modulation suggests it as a promising biomarker for SAH risk stratification and potential therapeutic strategies.
  • Further research is warranted to elucidate the mechanistic role of SLAMF1 in SAH pathophysiology.