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Related Experiment Video

Updated: Jan 11, 2026

3D Imaging of PDL Collagen Fibers during Orthodontic Tooth Movement in Mandibular Murine Model
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The NLRP3 Inflammasome Regulates Orthodontic Tooth Movement.

Lisa Latzko1, Gerald Degenhart2, Michael J Blumer3

  • 1University Hospital for Orthodontics, Department of Dental and Oral Medicine and Cranio-Maxillofacial and Oral Surgery, Medical University of Innsbruck, Innsbruck, Austria.

Orthodontics & Craniofacial Research
|November 12, 2025
PubMed
Summary

The NLRP3 inflammasome is crucial for early orthodontic tooth movement (OTM) but its role diminishes over time. Mice lacking NLRP3 showed delayed OTM initially, which resolved by day 21.

Keywords:
NLRP3 InflammasomeTRAPmicro‐CTorthodontic tooth movement

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Area of Science:

  • Immunology
  • Orthodontics
  • Cell Biology

Background:

  • The NLRP3 inflammasome acts as a damage sensor, mediating pyroptotic cell death during orthodontic tooth movement (OTM).
  • Previous research indicated impaired OTM in NLRP3-deficient mice after one week, but its role in long-term OTM is unclear.

Purpose of the Study:

  • To investigate the role of the NLRP3 inflammasome in both early and long-term orthodontic tooth movement (OTM).

Main Methods:

  • Orthodontic tooth movement (OTM) was analyzed in NLRP3-deficient (NLRP3-/-) and wild-type (WT) mice at 7, 14, and 21 days.
  • Micro-computed tomography (μCT) assessed molar movement and bone quality.
  • Tartrate-resistant acid phosphatase (TRAP) staining quantified osteoclastic activity.

Main Results:

  • OTM was delayed in NLRP3-/- mice at 14 days but recovered by day 21.
  • Alveolar bone loss occurred in both NLRP3-/- and WT mice.
  • NLRP3-/- mice exhibited fewer TRAP-positive osteoclasts compared to WT males at 14 and 21 days.

Conclusions:

  • NLRP3 plays a significant role in the early stages of OTM.
  • Its involvement appears less critical during later phases of orthodontic tooth movement.