Related Experiment Video

Updated: Jan 11, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.5K

Managing dyslipidemia in chronic kidney disease: a comprehensive overview of evidence and recommendations

Ji Yoon Kim1, Suk Min Chung2,3, Nam Hoon Kim4

  • 1Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

The Korean Journal of Internal Medicine
|November 12, 2025
PubMed

Insights

Managing dyslipidemia in chronic kidney disease (CKD) is crucial for reducing cardiovascular disease (CVD) risk. Tailored lipid-lowering strategies are essential due to unique pathophysiological mechanisms in CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Patients with chronic kidney disease (CKD) face a substantially elevated risk of cardiovascular disease (CVD).
  • Dyslipidemia management is a cornerstone of cardiovascular risk reduction in CKD.
  • Altered lipid profiles and unique pathophysiological mechanisms in CKD necessitate specialized treatment approaches.

Purpose of the Study:

  • To review clinical trials on lipid-lowering therapies in CKD patients.
  • To compare international and regional clinical practice guidelines for dyslipidemia in CKD.
  • To analyze cardiovascular outcomes of various lipid-lowering agents in CKD.

Main Methods:

  • Systematic review of clinical trials and guideline comparison.
  • Assessment of cardiovascular outcomes for statins, ezetimibe, PCSK9 inhibitors, fibrates, and omega-3 fatty acids.
  • Discussion of therapeutic strategies for different CKD patient subgroups (pre-dialysis, dialysis, transplant recipients).

Main Results:

  • Evidence synthesis on the efficacy and safety of lipid-lowering agents in CKD.
  • Comparative analysis of guideline recommendations for dyslipidemia management.
  • Identification of optimal strategies for diverse CKD populations.

Conclusions:

  • Tailored lipid-lowering therapies are vital for managing CVD risk in CKD.
  • Guideline adherence and individualized treatment plans are recommended.
  • Further research may refine therapeutic approaches for specific CKD subgroups.

Keywords:
DialysisDyslipidemiasHydroxymethylglutaryl-CoA reductase inhibitorsKidney transplantationRenal insufficiency, chronic

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.0K
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

14.0K

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
331
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
308
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
537
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
552
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
307
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.3K