Related Experiment Video
Updated: Jan 11, 2026

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
Published on: December 3, 2016
[Osteochondrosis in children and adolescents]
Matthias C Schaal1, Rita Taurman2, Kornelia Kreiser3
1Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland. matthias.schaal@uniklinik-ulm.de.
Background:
Osteochondrosis in children and adolescents is a group of diseases and not a variant of growth. They often occur during periods of rapid growth, with predilection sites at many epiphyses and apophyses as well as along the growth plates. There is a classic age of onset for each of the many different diseases.
Objectives:
Presentation of the most important entities (Perthes disease, Köhler I disease, Sever's disease, Osgood-Schlatter disease, Sinding-Larsen-Johansen disease, Scheuermann's disease).
Materials And Methods:
Presentation of the entities mentioned with the clinical presentation and a brief overview of the therapy; radiological changes are illustrated.
Results:
In various cases, the diagnosis can be made solely on clinical grounds. If imaging is necessary, conventional X‑rays are usually taken. In Perthes disease, a magnetic resonance imaging scan is indicated in the early stages of the disease.
Conclusion:
It is important to be aware of the predilection sites and the age of manifestation of the respective disease. If treatment is necessary, it will be based on the radiological changes, among other things. Correct implementation and diagnosis (in close cooperation with the clinical colleagues) are therefore essential.
Related Concept Videos
Bone Formation by Endochondral Ossification
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Growth of Cartilage and Bone Tissue
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
Bone Remodeling

