Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

179
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
179
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

141
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
141
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

162
Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
162
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

208
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
208
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

293
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
293
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

225
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
225

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Financial Toxicity Among Patients With Traumatic Finger Amputation: A Retrospective Study.

Hand (New York, N.Y.)·2024
Same author

Prescriptions for Mitigating Climate Change-Related Externalities in Cancer Care: A Surgeon's Perspective.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2022
Same author

Variations in mortality in Medicare recipients on extracorporeal membrane oxygenation.

Perfusion·2022
Same author

Raising Medicaid Rebates For Drugs With Accelerated Approval.

Health affairs (Project Hope)·2021
Same author

Payer-Specific Negotiated Prices for Prescription Drugs at Top-Performing US Hospitals.

JAMA internal medicine·2021
Same author

How Should Clinicians and Organizations Assess Risks and Benefits of First-in-Human Implantation of Investigational Devices?

AMA journal of ethics·2021

Related Experiment Video

Updated: Jan 11, 2026

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
06:34

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices

Published on: November 29, 2024

591

Enhancing Formulary Accessibility: a Step Toward Better Care.

Victor C Agbafe1,2,3, Aaron S Kesselheim4, John S Barbieri5

  • 1University of Michigan Medical School, Ann Arbor, MI, USA.

Journal of General Internal Medicine
|November 12, 2025
PubMed
Summary

Improving drug formulary accessibility enhances patient care and medication adherence. Greater transparency and integration into electronic health records can streamline prescribing and reduce administrative burdens for better health outcomes.

More Related Videos

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation
03:49

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation

Published on: October 11, 2024

1.2K
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.3K

Related Experiment Videos

Last Updated: Jan 11, 2026

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
06:34

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices

Published on: November 29, 2024

591
Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation
03:49

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation

Published on: October 11, 2024

1.2K
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.3K

Area of Science:

  • Health Policy
  • Pharmacoeconomics
  • Health Informatics

Background:

  • Drug formularies list covered medications but often contain complex features like prior authorization and tiered pricing.
  • These features can lead to patient confusion, non-adherence, and administrative burdens for healthcare providers.
  • Current formulary systems present barriers to optimal medication management and patient care.

Purpose of the Study:

  • To explore the impact of enhanced drug formulary accessibility on patient care and medication adherence.
  • To identify strategies for improving formulary transparency and integration within healthcare systems.
  • To examine the potential role of federal legislation in mandating formulary transparency.

Main Methods:

  • Literature review on existing formulary systems and their impact on patient outcomes.
  • Analysis of potential benefits of integrating formularies into electronic health records (EHRs).
  • Examination of policy mechanisms, including federal legislation, for enhancing formulary transparency.

Main Results:

  • Enhanced formulary accessibility can streamline prescribing, reduce administrative tasks, and improve patient counseling.
  • Integration with EHRs can help clinicians align treatment plans with coverage, reducing prior authorization delays.
  • Increased transparency can facilitate informed decision-making for patients and providers, optimizing formulary design.

Conclusions:

  • Improving drug formulary accessibility is crucial for enhancing patient care and medication adherence.
  • Greater transparency and integration into EHRs are key strategies for streamlining medication management.
  • Policy interventions, such as federal mandates for transparency, can foster a more patient-centric healthcare system.