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Venous Thromboembolism in Inherited Platelet Disorders: A Clinical Challenge.
Francesco Paciullo1, Patrizia Rovere-Querini1,2, Loredana Bury3
1Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Diagnostics (Basel, Switzerland)
|November 13, 2025
Summary
Inherited platelet disorders (IPDs) increase venous thromboembolism (VTE) risk despite lower apparent risk. Managing VTE in IPD patients is challenging due to bleeding and clotting concerns, especially during surgery.
Area of Science:
- Hematology
- Thrombosis and Hemostasis
Background:
- Inherited platelet disorders (IPDs) are rare conditions affecting platelet number or function.
- Patients with IPDs have a paradoxical risk of venous thromboembolism (VTE), a significant mortality cause.
- VTE management in IPD patients is complex due to balancing bleeding and clotting risks.
Purpose of the Study:
- To review the incidence and risk factors of VTE in IPD patients.
- To outline VTE management strategies for IPD patients.
- To focus on perioperative VTE considerations in IPD.
Main Methods:
- Literature review of current evidence.
- Synthesis of data on VTE incidence and risk factors in IPD.
- Analysis of VTE treatment and prevention strategies.
Main Results:
- VTE is a persistent risk in IPD patients, despite a seemingly lower incidence.
- Identifying specific risk factors for VTE in this population is crucial.
- Perioperative management requires careful consideration of antithrombotic therapy.
Conclusions:
- VTE poses a significant, albeit complex, risk in IPD patients.
- Effective VTE prevention and treatment strategies are essential, particularly in surgical settings.
- Further research is needed to optimize VTE care for individuals with IPDs.
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