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Updated: Jan 11, 2026
05:37
Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
1.1K
From Triads to Tools: A Comprehensive Review of the Expanding Roles of G-Triplex Structures.
Mitchell W Myhre1, Malay Kumar Das2, Elizabeth P Williams1
1Department of Chemistry & Biochemistry, Texas State University, San Marcos, TX 78666, USA.
Molecules (Basel, Switzerland)
|November 13, 2025
Summary
G-triplex DNA and RNA are novel non-canonical structures with growing interest. This review comprehensively surveys their formation, structure, and applications in biosensing and medicine.
Area of Science:
- Molecular Biology
- Biochemistry
- Structural Biology
Background:
- Non-canonical DNA structures, including G-triplex DNA, are gaining attention.
- G-triplex DNA, initially proposed as G-quadruplex intermediates, can form from specific sequences.
- This review provides a comprehensive survey of G-triplex DNA and RNA literature up to 2024.
Purpose of the Study:
- To survey the existing literature on G-triplex DNA and RNA.
- To detail the structural characteristics and formation of G-triplexes.
- To explore the applications and biological relevance of G-triplex structures.
Main Methods:
- Literature review of G-triplex DNA and RNA studies.
- Analysis of structural characterization data.
- Examination of sequence and environmental effects on G-triplex formation.
Main Results:
- G-triplex DNA and RNA structures have been characterized using various approaches.
- Sequence and environmental factors influence G-triplex formation, posing challenges like polymorphism.
- G-triplexes show potential in biosensing, protein recognition, and in vitro DNA replication effects.
Conclusions:
- G-triplex structures offer promising applications in biotechnology, medicine, and research.
- Further research is needed to develop selective ligands for G-triplexes.
- G-triplexes represent an important area of non-canonical nucleic acid research.
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