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Exploratory Gene Expression Profiling of Cisplatin-Induced Neurotoxicity in Rat Brain
Osvaldo Torres-Pineda1, Consuelo Morgado-Valle1, Donají Chi-Castañeda1
1Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91190, Veracruz, Mexico.
International Journal of Molecular Sciences
|November 13, 2025
Summary
This study maps cisplatin
Area of Science:
- Neuroscience
- Genomics
- Pharmacology
Background:
- Cisplatin is a key chemotherapy drug.
- Neurotoxicity limits its use.
- Molecular mechanisms of neurotoxicity are unclear.
Purpose of the Study:
- Characterize the brain's transcriptomic response to cisplatin.
- Identify molecular pathways involved in cisplatin neurotoxicity.
- Generate hypotheses for neuroprotective strategies.
Main Methods:
- Microarray analysis of male Wistar rat brains.
- Bioinformatic analyses: KEGG, GO, PPI networks.
- In silico correlation with human lower-grade glioma (LGG) data.
Main Results:
- Identified significant gene expression changes in synaptic signaling, neuroplasticity, and metabolism pathways.
- Discovered potential links between cisplatin-affected genes and LGG prognosis.
- Found associations with immune cell infiltration patterns in LGG.
Conclusions:
- Provided a comprehensive transcriptomic map of cisplatin neurotoxicity.
- Identified novel molecular targets for neuroprotection.
- Findings are hypothesis-generating and require further validation.
