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Updated: Jan 11, 2026

Electrophysiology on Isolated Brainstem-spinal Cord Preparations from Newborn Rodents Allows Neural Respiratory Network Output Recording
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Gαi2 Signaling Regulates Neonatal Respiratory Adaptation

Veronika Leiss1, Katja Pexa2, Andreas Nowacki1

  • 1Department of Pharmacology, Experimental Therapy and Toxicology, Institute of Experimental and Clinical Pharmacology and Pharmacogenomic, Interfaculty Center for Pharmacogenomics and Drug Research, Eberhard Karls University Tübingen and University Clinic, 72076 Tübingen, Germany.

International Journal of Molecular Sciences
|November 13, 2025
PubMed
Summary

Gαi2 deficiency impairs neonatal respiratory adaptation, causing mortality in newborn mice due to breathing difficulties. This highlights Gαi2's role in lung development and surfactant function.

Keywords:
Gαi-signalingGαi2lung developmentneonatal lethalityrespiratory distress syndrome (RDS)surfactant

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