Expert Perspectives on Enhancing Analytical Methods for Multi-Ingredient Dietary Supplements (MIDS): A Qualitative...

Area of Science:

• Analytical Chemistry
• Food Science
• Pharmacology

Background:

• The growing market for multi-ingredient dietary supplements (MIDS) presents significant analytical challenges.
• Complex ingredient interactions and formulation variability complicate quality control and product testing.

Purpose of the Study:

• To investigate the analytical challenges encountered in multi-ingredient dietary supplement (MIDS) testing.
• To explore practical solutions and identify areas for improvement in MIDS quality assurance.

Main Methods:

• Semi-structured focus group interviews were conducted with 33 industry professionals and 10 analytical experts.
• Qualitative data analysis was used to identify obstacles and proposed solutions.

Main Results:

• Key challenges include trace component degradation, ingredient interference, dosage form difficulties, and lack of standardized protocols.
• Industry professionals employ internal, company-specific strategies like raw material substitution and modified analytical procedures.
• Analytical experts recommend matrix-specific pretreatment, optimized extraction, and regulatory harmonization.

Conclusions:

• Current MIDS testing lacks a unified analytical framework, leading to varied internal solutions.
• Standardized methodologies and regulatory harmonization are crucial for enhancing analytical reliability and reproducibility in MIDS analysis.
• The study provides insights for developing robust quality assurance frameworks for MIDS.