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Six-Month Local Control Rates and Immune Responses After Pulsed Electric Field Ablation in Metastatic Cancer.

Alicia Moreno-Gonzalez1, Ebtesam H O Nafie1, Chiara Pastori1

  • 1Galvanize Therapeutics Inc., Redwood City, CA 94065, USA.

Cancers
|November 13, 2025
PubMed
Summary

Aliya pulsed electric field ablation shows promise for local tumor control and immune system modulation in solid tumors. Six-month follow-up suggests potential efficacy, warranting further investigation into this novel energy modality.

Keywords:
ablationimmunological changeslung cancermetastatic cancerpulsed electric fields

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Area of Science:

  • Oncology
  • Immunology
  • Medical Technology

Background:

  • The AFFINITY trial (NCT05890872) is a prospective, single-arm study assessing Aliya pulsed electric field ablation for solid tumors.
  • The study focuses on safety, immunological impact, and preliminary efficacy, with a specific look at six-month local control and immune responses.

Purpose of the Study:

  • To evaluate the six-month local control outcomes of Aliya pulsed electric field ablation in patients with solid tumors.
  • To assess the immunological impact, including changes in immune cell populations and immunoglobulin responses, following ablation.

Main Methods:

  • Radiological assessment using modified RECIST 1.1 at 1, 3, and 6 months post-ablation for local control evaluation.
  • Peripheral blood immune monitoring via flow cytometry and detection of IgG responses to tumor antigens.

Main Results:

  • In the ablation-only group (n=12), all ablated lesions demonstrated local control at 6 months (8/12 stable disease, 4/12 partial response).
  • Immunophenotyping revealed dynamic changes in circulating immune cells, including T and B cell activation.
  • A subset of patients showed modulation of tumor antigen-specific IgG, indicating a systemic humoral response.

Conclusions:

  • Aliya pulsed electric field ablation demonstrates preliminary potential for promoting local tumor control in solid tumors.
  • The ablation technique may modulate systemic immune function, suggesting an immunogenic effect.
  • Further investigation is warranted to explore the full potential of this specialized energy modality.