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Updated: Jan 11, 2026

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Berries derived Polyphenols and Bone Health: A Systematic Review.

Simone Perna1, Giorgia F Ruina1, Asmita Acharya1

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|November 13, 2025
PubMed
Summary
This summary is machine-generated.

Berries, rich in antioxidants, show potential for improving bone health by reducing oxidative stress and inflammation. However, more robust clinical trials are needed to confirm these benefits for osteoporosis prevention.

Keywords:
anthocyaninsberry polyphenolsbone mineral density (BMD)bone remodelingosteoblast and osteoclast activityosteoporosis preventionoxidative stress

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Area of Science:

  • Nutritional Science
  • Bone Biology
  • Pharmacology

Background:

  • Osteoporosis pathogenesis involves oxidative stress and inflammation.
  • Berries contain polyphenols, particularly anthocyanins, with potential bone-modulating properties.
  • This review is the first to comprehensively synthesize evidence on berries and bone health.

Purpose of the Study:

  • To systematically review and synthesize evidence on the effects of berries and berry-derived compounds on bone health.
  • To integrate human, animal, and in vitro data using the GRADE framework.
  • To assess the certainty of evidence for berry consumption and bone outcomes.

Main Methods:

  • Systematic literature search across major databases (PubMed, Embase, Web of Science, Scopus, Cochrane Library) up to April 2025.
  • Inclusion of human, animal, and in vitro studies investigating berries/compounds and bone outcomes.
  • Risk of bias assessment and GRADE certainty appraisal of human evidence.

Main Results:

  • Nineteen studies (5 human, 9 in vivo, 5 in vitro) were included.
  • Observational data suggest higher anthocyanin intake correlates with greater bone mineral density (BMD).
  • Limited human trials show modest effects on BMD and bone turnover markers; animal and in vitro studies indicate protective effects against bone loss.

Conclusions:

  • Berry polyphenols may support skeletal health through antioxidant and anti-resorptive mechanisms.
  • Current clinical evidence is limited by small sample sizes, heterogeneity, and lack of fracture data.
  • Larger, standardized randomized controlled trials (RCTs) are necessary to establish dietary recommendations.