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Updated: Jan 11, 2026
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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
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Nanoemulsion Gel as a Novel Delivery System for Phytoconstituents: An Innovative Approach for Improved Solubility,
Arnima Sharma1, Ankur Kapil1, Abhishek Pandey1
1School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, 474011, India.
Recent Advances in Drug Delivery and Formulation
|November 13, 2025
Summary
Nanoemulgel formulations enhance the delivery of poorly soluble plant-derived compounds (phytoconstituents) for improved therapeutic effects. This novel approach boosts solubility, absorption, and bioavailability for various applications.
Area of Science:
- Pharmaceutical Science
- Nanotechnology
- Natural Product Chemistry
Background:
- Phytoconstituents offer diverse therapeutic benefits but face delivery challenges like poor solubility and low bioavailability.
- Nanoemulsions, with droplet sizes from 20-500 nm, are effective carriers for these bioactive compounds.
- Nanoemulgel technology addresses these limitations by enhancing solubility, permeability, and stability.
Purpose of the Study:
- To review the preparation methods and applications of phytoconstituent-loaded nanoemulgels.
- To highlight the role of nanoemulsions in overcoming phytoconstituent delivery barriers.
- To explore the therapeutic potential of nanoemulgels in various disease conditions.
Main Methods:
- Review of literature on nanoemulsion preparation techniques (high-energy and low-energy approaches).
- Discussion of nanoemulsion stability parameters.
- Compilation of studies on phytoconstituent-loaded nanoemulgels for diverse applications.
Main Results:
- Nanoemulgels significantly enhance the solubility, absorption, and bioavailability of loaded phytoconstituents.
- 33 phytoconstituent-loaded nanoemulgels show efficacy in treating rheumatoid arthritis, cancer, inflammation, wound healing, and skin disorders.
- 11 additional nanoemulgels demonstrate benefits across numerous other disease conditions.
Conclusions:
- Nanoemulgel technology is a promising platform for delivering phytoconstituents, improving their therapeutic efficacy.
- The enhanced properties of nanoemulsions overcome major hurdles in phytoconstituent drug delivery.
- Further research into phytoconstituent-based nanoemulgels can unlock new treatment possibilities.
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