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Nonpenetrating deep sclerectomy: Challenges, innovations, and current evidence.

Ahmed Mostafa Abdelrahman1

  • 1Department of Ophthalmology, Cairo University, Giza, Egypt.

Oman Journal of Ophthalmology
|November 13, 2025
PubMed
Summary

Nonpenetrating deep sclerectomy (NPDS) offers a safe and effective glaucoma treatment, gradually lowering intraocular pressure. This review explores NPDS techniques, innovations, and outcomes across various glaucoma types and stages.

Keywords:
Ahmed sutureglaucomaintraocular pressurenonpenetrating deep sclerectomyprimary open-angle glaucomasutureless nonpenetrating glaucoma surgery

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Area of Science:

  • Ophthalmology
  • Glaucoma Surgery

Background:

  • Nonpenetrating deep sclerectomy (NPDS) is a surgical technique developed in 1989.
  • It is recognized for its favorable safety profile and efficacy in managing glaucoma.
  • NPDS facilitates a controlled, gradual reduction in intraocular pressure compared to other procedures.

Purpose of the Study:

  • To review the technique of Nonpenetrating deep sclerectomy (NPDS).
  • To summarize challenges, innovations, and outcomes associated with NPDS.
  • To cover NPDS applications in various glaucoma types and disease stages.

Main Methods:

  • Literature review of Nonpenetrating deep sclerectomy (NPDS).

Main Results:

  • NPDS demonstrates significant safety and good efficacy.
  • The procedure leads to a controlled and gradual reduction of intraocular pressure.
  • Evidence supports NPDS for various glaucomas and disease stages.

Conclusions:

  • Nonpenetrating deep sclerectomy (NPDS) is a valuable surgical option for glaucoma.
  • Ongoing innovations continue to refine NPDS techniques and outcomes.
  • Further research can optimize NPDS for diverse patient populations and glaucoma severities.