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AC/DC: Highway to cell
Victor Bosteels1, William Stainier1, Caetano Reis E Sousa1
1Immunobiology Laboratory, Francis Crick Institute , London, UK.
The Journal of Experimental Medicine
|November 13, 2025
Abstract
None:
Apoptotic cell (AC) corpses can be taken up by certain types of dendritic cell (DC), which cross-present dead cell-derived antigens. In this issue of JEM, Tam et al. (https://doi.org/10.1084/jem.20250887) reveal that GPR34, a lysophosphatidylserine receptor, promotes AC uptake and cross-presentation by type 1 DCs (cDC1s).
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