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Do Updated Calcitonin Thresholds More Accurately Predict Lymph Node Metastasis in Medullary Thyroid Cancer?

Agostino Colli1

  • 1Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.

JAMA Otolaryngology-- Head & Neck Surgery
|November 13, 2025
PubMed
Abstract

No abstract available in PubMed .

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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