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An Overview of Nocebo Adverse Events in Clinical Trials
Martina Amanzio1, Giuseppina Elena Cipriani2
1Department of Psychology, University of Turin, Via Verdi 10, Turin 10124, Italy.
Abstract:
The nocebo effect has a significant impact on clinical trials and patient care. It leads to more frequent reports of adverse events, higher drop-out rates, and biased judgements of treatment efficacy. This review summarizes the findings from different disease areas and highlights the importance of psychological factors in treatment outcomes. Effective communication, patient awareness, and understanding of nocebo effects are critical to minimizing these reactions, improving patient adherence, and increasing the validity of clinical trials. Dealing with nocebo side effects is critical to optimizing patient care and treatment success.
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