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Updated: Jan 11, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[Transfusion support in elderly patients undergoing cancer treatment: ethical and technical issues]
Katayoun Jondeau1, Marine Bounin2, Marie-Dominique Venon1
1Hématologie clinique, université Paris Saclay, site Ambroise-Paré, AP-HP, 9 avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France; Unité de médecine ambulatoire, université Paris Saclay, site Ambroise-Paré, AP-HP, 9 avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.
Abstract:
Anemia is a key factor in quality of life and the risk of age-related complications such as loss of independence and worsening neurocognitive disorders in elderly patients being treated for malignant blood disorders. The transfusion threshold, which has been little studied in this context, must take these parameters into account, especially since patients, including the very elderly, can increasingly benefit from curative treatments for malignant blood disorders and some do not respond to or are not indicated for erythropoiesis-stimulating agents. Furthermore, in France, treatment with packed red blood cells and transfusion protocols have significantly reduced the risks of transfusion-related complications.
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