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Updates on Multimodal Analgesia for Orthopedic Surgery
Jeffrey J Mojica1, David Rubin2, Michael Mastria2
1Department of Anesthesiology & Perioperative Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, 111 South Eleventh Street, Suite 8280, Philadelphia, PA 19107, USA.
Anesthesiology Clinics
|November 13, 2025
Summary
Multimodal analgesia is the standard for orthopedic surgery, using multiple nonopioid drugs to enhance pain relief and recovery. This review explores new analgesics and their effectiveness in orthopedic procedures.
Area of Science:
- Orthopedic Surgery
- Pain Management
- Pharmacology
Background:
- Multimodal analgesia is now standard in orthopedic surgery.
- It utilizes various nonopioid analgesics to target diverse pain pathways.
- The goal is to improve pain relief, decrease opioid use, and aid functional recovery.
Purpose of the Study:
- To review novel analgesic agents.
- To examine the evidence for their efficacy in orthopedic surgery.
Main Methods:
- Literature review of recent studies.
- Analysis of clinical trial data on novel analgesics.
- Synthesis of evidence regarding pain management in orthopedics.
Main Results:
- Emerging analgesics show promise in improving pain control.
- Evidence supports reduced opioid consumption with multimodal approaches.
- Enhanced functional recovery is associated with these strategies.
Conclusions:
- Novel analgesics offer potential advancements in orthopedic pain management.
- Optimizing multimodal strategies is key to improving patient outcomes.
- Further research is warranted to fully elucidate the role of new agents.
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