C-reactive protein as an effector molecule in dengue pathogenesis: a review

Area of Science:

• Infectious Diseases
• Immunology
• Pathogenesis

Background:

• Dengue virus, transmitted by Aedes aegypti mosquitoes, is a major global arboviral infection.
• Dengue induces significant immune activation and inflammation.
• C-reactive protein (CRP) is a known inflammation marker, but its specific role in dengue pathogenesis requires further investigation.

Purpose of the Study:

• To review and summarize current literature on factors affecting dengue pathogenesis mediated by CRP.
• To elucidate the specific mechanisms through which CRP influences dengue disease progression.

Main Methods:

• Comprehensive literature search of PubMed, Embase, and Web of Science databases.
• Analysis of published studies up to 2025 focusing on CRP and dengue.

Main Results:

• CRP's role in dengue pathogenesis is linked to complement activation.
• CRP influences coagulation system alterations and thrombocytopenia.
• CRP affects vascular permeability, liver damage, and immune cell interactions (Fc receptors, dendritic cells).

Conclusions:

• CRP is strongly implicated as an effector molecule in dengue pathogenesis.
• Understanding CRP's mechanisms can offer insights into dengue disease severity and potential therapeutic targets.