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Electroacupuncture improves motor function after ischemic stroke via regulating mitochondrial dynamics.

Zuanfang Li1, Xinru Ji2, Xiuxiu Wang3

  • 1National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Rehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Innovation and Transformation Center, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.

Brain Research Bulletin
|November 14, 2025
PubMed
Summary

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This summary is machine-generated.

Electroacupuncture (EA) therapy improved motor function in rats with ischemic stroke by regulating mitochondrial dynamics, enhancing glucose metabolism, and boosting ATP production.

Area of Science:

  • Neuroscience
  • Integrative and Complementary Medicine
  • Biochemistry

Background:

  • Middle cerebral artery occlusion (MCAO) in rats is a model for ischemic stroke.
  • Electroacupuncture (EA) shows promise in protecting against MCAO and improving motor function.
  • The precise mechanisms underlying EA's therapeutic effects in MCAO require further investigation.

Purpose of the Study:

  • To investigate the effects of EA at the Quchi (LI11) and Zusanli (ST36) acupoints on motor function in MCAO rats.
  • To elucidate the underlying mechanisms, focusing on mitochondrial dynamics, glucose metabolism, and ATP production.

Main Methods:

  • MCAO rat model established, with EA applied to LI11 and ST36 acupoints.
  • Assessment of motor function using Catwalk gait analysis.
Keywords:
ElectroacupunctureMiddle cerebral artery occlusionMitochondrial dynamicsMotor function

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  • Evaluation of cerebral infarct volume, cortical morphology, glucose metabolism (CEST), ATP levels, mitochondrial morphology (TEM), and expression of mitochondrial dynamics genes (Drp1, Fis1, Mfn2, Mfn1, Opa1) via Western blot and qPCR.

    • Main Results:

    • EA treatment improved gait dynamics and reduced cerebral infarct volume and cortical damage.
    • EA significantly alleviated mitochondrial morphological changes and disorders.
    • EA upregulated Opa1 and downregulated Drp1, improving mitochondrial dynamics, glucose metabolism, and ATP production.

    Conclusions:

    • EA regulates mitochondrial dynamics to improve glucose metabolism dysfunction.
    • This regulation by EA ultimately restores motor function in MCAO rats.