Related Experiment Video
Updated: Jan 6, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
LMNB2 Regulates Esophageal Carcinoma Stemness and Warburg Effect by Modulating the p38 MAPK Signaling Pathway
Xiaofeng Zhu1, Xiaowen Zhao1, Yayun Cui2
1Division of Life Sciences and Medicine, Department of Gastroenterology, The First Affiliated Hospital of USTC, University of Science and Technology of China (Anhui Provincial Cancer Hospital), Hefei, 230031, Anhui, China.
Abstract:
Esophageal carcinoma (ESCA) represents a highly aggressive malignancy with limited therapeutic options. Mounting evidence indicated that Nuclear Lamin B2 (LMNB2) was involved in tumor progression through modulation of multiple signaling pathways. However, the investigation of LMNB2 role in tumor cell stemness and the Warburg effect remains inconclusive. This study utilized the UALCAN database to perform pan-cancer, clinical sample and cell line analyses. Western blot validation demonstrated substantial LMNB2 overexpression in ESCA cells. Silencing LMNB2 expression significantly repressed ESCA cells stemness and Warburg effect. Integrated bioinformatics analyses using Linkedomics, Funrich, and String databases identified the p38 MAPK pathway as a downstream mediator. In vitro experiments verified the regulatory impact of LMNB2 on the p38 phosphorylation in the MAPK signaling pathway, implicated in the regulation of tumor sphere formation and the Warburg effect. LMNB2 also exhibited a regulatory role in tumor growth within the mouse xenograft model. This study proposed that LMNB2 could emerge as a novel therapeutic strategy for treating ESCA.
More Related Videos
06:51Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
11:32Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
Published on: March 27, 2020
Related Concept Videos
Abnormal Proliferation
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
MAPK Signaling Cascades
Mitogens and the Cell Cycle
Master Transcription Regulators