Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.2K
Relative Risk01:12

Relative Risk

1.7K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accelerometer-Measured Moderate-to-Vigorous Physical Activity and Cancer Risk: Dose-Response from Observational and Nonlinear Mendelian Randomization in UK Biobank.

Healthcare (Basel, Switzerland)·2026
Same author

A Randomized, Nivolumab-controlled, Phase 2 and Biomarker Study of Lomvastomig and Tobemstomig in Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

From Leaky Gut to a Vulnerable Brain: Obesity-Associated Gut Barrier Failure in Colorectal Cancer and Cognitive Dysfunction.

Nutrients·2026
Same author

Circulating tumor-associated autoantibody signatures for diagnosis and prognosis in small-cell lung cancer and lung adenocarcinoma.

British journal of cancer·2026
Same author

Secretory LGALS3BP exacerbates sepsis-associated liver dysfunction by activating inflammasome-mediated pyroptosis.

Cell death discovery·2026
Same author

Systemic Lipid Peroxidation and Colorectal Cancer Risk: A Time-Varying Relationship.

International journal of cancer·2026

Related Experiment Video

Updated: Jan 6, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.5K

The Association between Genetically Predicted C-Reactive Protein Levels and Risk of Colorectal Cancer in an East

Chang Kyun Choi1, Jung-Ho Yang2, Min-Ho Shin2

  • 1Division of Cancer Early Detection, National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|November 14, 2025
PubMed
Summary

C-reactive protein (CRP) does not appear to causally increase colorectal cancer (CRC) risk in East Asians. This large genetic study found no significant link between CRP levels and CRC, suggesting CRP is not a key driver of this cancer.

More Related Videos

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

616
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.5K

Related Experiment Videos

Last Updated: Jan 6, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.5K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

616
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.5K

Area of Science:

  • Biomarkers
  • Genetics
  • Oncology

Background:

  • C-reactive protein (CRP) is an inflammatory biomarker linked to colorectal cancer (CRC) risk.
  • Observational studies face challenges like confounding and reverse causality.

Purpose of the Study:

  • To investigate the causal relationship between C-reactive protein (CRP) and colorectal cancer (CRC) risk using Mendelian randomization.
  • To assess the role of CRP in colorectal carcinogenesis in an East Asian population.

Main Methods:

  • Two-sample Mendelian randomization analysis.
  • Utilized genome-wide association study (GWAS) data for CRP and CRC from East Asian cohorts.
  • Analysis powered to detect modest effects on CRC risk.

Main Results:

  • Genetically predicted CRP levels showed no significant association with colorectal cancer risk.
  • Inverse-variance weighted odds ratio was 0.995 (95% CI: 0.893-1.109, P=0.929).
  • Sensitivity analyses confirmed the null findings, excluding horizontal pleiotropy.

Conclusions:

  • Limited evidence supports a causal association between CRP and CRC risk in East Asians.
  • CRP is unlikely to be a significant determinant of colorectal cancer development.
  • Findings align with previous research in European populations.