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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:

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Related Experiment Video

Updated: Jul 16, 2026

Visualization of Intensity Levels to Reduce the Gap Between Self-Reported and Directly Measured Physical Activity
05:59

Visualization of Intensity Levels to Reduce the Gap Between Self-Reported and Directly Measured Physical Activity

Published on: March 7, 2019

Accelerometer-Measured Moderate-to-Vigorous Physical Activity and Cancer Risk: Dose-Response from Observational and

Chang-Ling Huang1, Meng-Xuan Yang1, Yong-Qiao He2

  • 1School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

Healthcare (Basel, Switzerland)
|July 15, 2026
PubMed
Summary

Higher weekly moderate-to-vigorous physical activity (MVPA) is linked to reduced cancer risk. Objective measurements suggest approximately 5 hours weekly may optimize cancer prevention benefits.

Keywords:
Mendelian randomizationcancer incidencemoderate-to-vigorous physical activity (MVPA)nonlinear dose–responsephysical activity

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Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption
08:45

Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption

Published on: June 20, 2025

Related Experiment Videos

Last Updated: Jul 16, 2026

Visualization of Intensity Levels to Reduce the Gap Between Self-Reported and Directly Measured Physical Activity
05:59

Visualization of Intensity Levels to Reduce the Gap Between Self-Reported and Directly Measured Physical Activity

Published on: March 7, 2019

Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption
08:45

Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption

Published on: June 20, 2025

Area of Science:

  • Epidemiology
  • Genetics
  • Public Health

Background:

  • Physical activity is a known factor in cancer risk reduction.
  • Optimal weekly volume of moderate-to-vigorous physical activity (MVPA) for cancer prevention using objective measures is unclear.
  • Self-reported physical activity data may introduce bias, obscuring accurate dose-response relationships.

Purpose of the Study:

  • To determine the optimal weekly volume of MVPA for cancer prevention using objective measures.
  • To investigate the dose-response relationship between MVPA and cancer incidence.
  • To evaluate potential causal associations and dose-response patterns using Mendelian randomization.

Main Methods:

  • Analysis of UK Biobank participants with accelerometer data to quantify habitual MVPA.
  • Multivariable Cox proportional hazards regression and restricted cubic splines for observational associations.
  • One-sample Mendelian randomization (MR) analyses (linear and nonlinear) to assess causality.

Main Results:

  • Higher MVPA was significantly associated with lower total cancer risk (HR 0.971).
  • Associations were observed for lung, colorectal, breast, kidney, and bladder cancers.
  • MR analyses supported a causal link between genetically predicted MVPA and reduced cancer risk, with a potential nonlinear association around 5 hours weekly.

Conclusions:

  • Accelerometer-measured MVPA is associated with lower total cancer risk.
  • Findings support a dose-response relationship between MVPA and cancer incidence.
  • Objective measurement of MVPA provides valuable insights into cancer prevention strategies.