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Guangdong Biobank Cohort (GDBC) study.

Yong-Qiao He1, Wen-Qiong Xue2, Hua Diao3,4

  • 1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, 651 Dong Feng East Road, Guangzhou, Guangdong, P. R. China. heyq@sysucc.org.cn.

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Summary

The Guangdong Biobank Cohort (GDBC) study tracks non-communicable diseases (NCDs) in China. It aims to understand gene-environment interactions for better NCD prevention strategies.

Keywords:
Cloud-based multidimensional databaseGene–environment interactionsLongitudinal studyNon-communicable diseaseOral microbiotaPopulation-based cohort

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Area of Science:

  • Public Health
  • Epidemiology
  • Genetics

Background:

  • Non-communicable diseases (NCDs) pose a growing global health challenge, especially in rapidly transitioning economies.
  • Large-scale population cohorts are crucial for understanding region-specific NCD determinants.
  • Guangdong Province faces a significant and increasing NCD burden, yet lacks extensive cohort data.

Purpose of the Study:

  • Establish the Guangdong Biobank Cohort (GDBC) to investigate NCDs in a major Chinese population.
  • Collect comprehensive baseline and longitudinal data on lifestyle, environment, genetics, and health outcomes.
  • Facilitate research into gene-microbiome-environment interactions for precision prevention strategies.

Main Methods:

  • Recruited 35,081 participants aged 40-84 in Guangdong Province.
  • Collected extensive data (346 variables), biospecimens, and performed genome-wide genotyping and oral microbiome profiling.
  • Utilized dynamic follow-up, resurveys, and regional registry linkage for disease ascertainment until December 2023.

Main Results:

  • Baseline prevalence: hypertension (25.3%), diabetes (8.0%), cancer (3.6%).
  • Crude incidence rates per 100,000 person-years: hypertension (1,804.6), diabetes (649.7), cancer (423.1).
  • GDBC is a dynamic resource with repeated measurements and updated biospecimens.

Conclusions:

  • The GDBC is a valuable resource for studying NCDs in Guangdong Province.
  • The cohort enables detailed analysis of gene-microbiome-environment interactions.
  • Findings will inform precision prevention strategies and public health policies for NCDs.