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Updated: Jan 11, 2026
10:04
Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
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Dendritic cells: the central partner for cancer immunity
Léo Laoubi1,2, Elisa Gobbini1,3, Pierre Duplouye1
1Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, INSERM U1052, CNRS UMR5286, Université Claude Bernard Lyon 1, Lyon, France.
Oncoimmunology
|November 14, 2025
Summary
Dendritic cells (DCs) are key immune cells that bridge innate and adaptive immunity. This review explores how DCs initiate and regulate anti-tumor responses, interact with other immune cells, and are affected by the tumor microenvironment for cancer immunotherapy.
Area of Science:
- Immunology
- Cancer Biology
- Cellular Immunology
Background:
- Dendritic cells (DCs) are crucial immune cells bridging innate and adaptive immunity.
- DCs capture, process, and present tumor antigens to T cells, initiating anti-tumor responses.
Purpose of the Study:
- To review the phenotypic and functional diversity of DCs in cancer immunity.
- To emphasize DC interactions with other immune cells in the tumor microenvironment.
- To examine the impact of tumor signals and immunosuppression on DC function and immunotherapy.
Main Methods:
- Literature review of studies on dendritic cells in cancer immunity.
- Analysis of DC interactions within the tumor microenvironment.
- Examination of tumor-derived signals and immunosuppressive mechanisms affecting DCs.
Main Results:
- DCs exhibit significant phenotypic and functional heterogeneity in cancer.
- DC interactions with other immune cells are vital for effective anti-tumor immunity.
- Tumor microenvironment signals and immunosuppression impair DC functions.
Conclusions:
- Understanding DC diversity and function is critical for developing effective DC-based cancer immunotherapies.
- Targeting DC-mediated immune responses holds promise for cancer treatment.
- Overcoming tumor-induced immunosuppression is essential for successful DC-based immunotherapy.
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