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Updated: Jan 11, 2026

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
Dendritic cells: the central partner for cancer immunity
Léo Laoubi1,2, Elisa Gobbini1,3, Pierre Duplouye1
1Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, INSERM U1052, CNRS UMR5286, Université Claude Bernard Lyon 1, Lyon, France.
Abstract:
Dendritic cells (DCs) are central players in the immune system, serving as a bridge between innate and adaptive immunity. Their unique abilities to capture, process, migrate, and present tumor-associated antigens to T cells make them essential actors in initiating and regulating anti-tumor immune responses. This review provides an overview of the phenotypic heterogeneity and functional diversity of DC in cancer immunity, with an emphasis on their interactions with other immune cells within the tumor microenvironment, highlighting their collaborative efforts in driving effective antitumor immunity. Additionally, we examined the impact of tumor-derived signals and immunosuppressive mechanisms on DC functions and their implications for DC-based cancer immunotherapy.
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