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Updated: Jan 11, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
Cholesterol metabolism regulates macrophage function and inflammation-related diseases
Jun Xiao1, Shuang Wang2, Miao Jin3
1Department of Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China; Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
None:
Cholesterol is an essential lipid component of membrane bilayers that maintains proper cellular function. Macrophages, key innate immune cells, are involved in organ development, tissue repair, defense against infection, and tumor progression. Accumulating evidence indicates that macrophages undergo significant reprogramming of cholesterol metabolism in response to external signals from diverse pathological microenvironments. This review provides a comprehensive overview of the cellular and systemic regulation of cholesterol metabolism homeostasis and examines how cholesterol metabolites regulate macrophage function. It highlights recent advances in targeting cholesterol metabolism for therapeutic purposes in various human diseases, including neurodegenerative diseases, atherosclerosis, bacterial and viral infections, and cancer.
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