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Multiple sclerosis-associated uveitis successfully controlled with ofatumumab.

Soufiane Azargui1, Julia L Xia1, Ian J McClain1

  • 1Department of Ophthalmology, University of Colorado School of Medicine, 1675 Aurora Court, F731, Aurora, CO, 80045, USA.

Journal of Ophthalmic Inflammation and Infection
|November 14, 2025
PubMed
Summary
This summary is machine-generated.

Ofatumumab effectively treated multiple sclerosis (MS)-associated uveitis in three patients. This B-cell therapy offers a promising self-administered option for ocular inflammation in MS patients.

Keywords:
KesimptaMultiple sclerosisOfatumumabRetinal vasculitisUveitis

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Area of Science:

  • Ophthalmology
  • Neurology
  • Immunology

Background:

  • Multiple sclerosis (MS) can be associated with ocular inflammation, specifically uveitis.
  • Current treatments for MS-associated uveitis may have limitations or require complex administration.

Purpose of the Study:

  • To report the successful use of ofatumumab in treating multiple sclerosis-associated uveitis.
  • To highlight ofatumumab as a potential therapeutic option for MS-related ocular inflammation.

Main Methods:

  • Three case studies of patients with MS-associated uveitis are presented.
  • Patients received treatment with ofatumumab, with outcomes monitored via clinical examination and fluorescein angiography (FA).

Main Results:

  • All three patients demonstrated significant improvement in ocular inflammation, including reduced vitreous cells and vascular leakage.
  • One patient successfully transitioned from other therapies to ofatumumab, maintaining disease quiescence.

Conclusions:

  • Ofatumumab appears to be an effective treatment for multiple sclerosis-associated uveitis.
  • The self-administered nature of ofatumumab presents an advantage for patient convenience.
  • Further research is warranted to identify optimal candidates for ofatumumab therapy in MS-associated uveitis.