Related Experiment Video
Updated: Jan 11, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Influencing factors of depressive symptoms in middle-aged and elderly people and its regional differences in china: a
Xin-Yue Gong1,2, Qi Cheng1, Ying-Ting Wu1
1School of Nursing, Anhui University of Chinese Medicine, No. 350 Longzihu Street, New Station Area, Hefei, 230012, China.
Background:
This study aims to explore the influencing factors and regional differences in the presence of depressive symptoms (DS) among middle-aged and elderly people in China, as well as to explore the network relationship among the influencing factors by constructing Bayesian networks (BNs) model.
Methods:
A total of 3582 respondents were included using China Health and Retirement Longitudinal Study (CHARLS) 2020 data. Logistic regression analysis was used to screen for variables related to DS. And the intricate conditional dependencies were visualized by BNs. Differences in the spatial distribution of DS were visualized by a geographic information system.
Results:
During the COVID-19 epidemic, the prevalence of DS in China was 46.5%. The high prevalence areas of DS were mainly clustered in the west (Sichuan, Qinghai) and middle (Hubei, Henan) regions of China. The results showed that the occurrence of DS among middle-aged and elderly people exhibits a direct probabilistic dependency with gender, body pain, self-reported health status, IADL (Instrument Activities of Daily Living), length of night sleep and region. Concurrently, age, education, chronic diseases, marital status and BADL (Basic Activities of Daily Living) were found to have an indirect probabilistic dependency with the prevalence of DS in these individuals.
Conclusions:
The overall prevalence of DS remains high among middle-aged and older adults. Predominantly, the hotspots for high prevalence of DS are concentrated in middle and west regions of China. By identifying the most direct risk factors for DS, healthcare providers and community workers can develop targeted interventions to prevent and manage this condition.
More Related Videos
08:15Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
07:58Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
Published on: February 24, 2023
Related Concept Videos
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depression: Overview
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Depressive Disorders: MDD and Dysthymia
Relationship Formation