Norming of the NIH Toolbox Cognition Battery Version 3.

Area of Science:

• Neuroscience
• Psychology
• Biostatistics

Background:

• The NIH Toolbox Cognition Battery (NIHTB-CB) is a widely used neuropsychological assessment tool.
• Previous versions have supported clinical and large-scale research applications.
• An updated Version 3 (V3) required re-norming to reflect current U.S. population demographics.

Purpose of the Study:

• To describe the methodology for establishing normative reference values for the updated NIHTB-CB V3.
• To ensure the assessment tool provides accurate cognitive function measures for diverse populations.

Main Methods:

• Administered NIHTB-CB tests to a large, demographically stratified U.S. sample (n=3,904).
• Utilized iterative proportional fitting (raking) to match sample demographics to U.S. Census targets.
• Employed regression-based continuous norming and bootstrap techniques to generate normative scores.

Main Results:

• Normative data were collected from a diverse sample representative of the U.S. population.
• Sampling weights were derived to align participant demographics with U.S. Census data.
• Age-adjusted and age-and-education-adjusted normative scores were developed for individual and composite measures.

Conclusions:

• The NIHTB-CB V3 provides updated, robust normative data for neuropsychological assessment.
• The re-norming process ensures the tool's continued utility in research and clinical settings.
• These updated norms facilitate more accurate interpretation of cognitive function across varied demographic groups.