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Updated: Jun 23, 2026

Clean Sampling and Analysis of River and Estuarine Waters for Trace Metal Studies
Published on: July 1, 2016
Bubble preconcentration coupled with SALDI-TOF MS for rapid detection of PFAS in environmental water
Zhi-Yang Huang1, Ming Jhe Hu2, Ling-I Hung3
1Department of Chemistry, National Chung Hsing University, Taichung City, 402202, Taiwan.
Abstract:
Per- and polyfluoroalkyl substances (PFASs) are highly persistent and bioaccumulative contaminants that pose serious ecological and human health risks even at trace levels. In this study, we developed a rapid and eco-friendly bubble preconcentration-surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS) method for PFAS detection in water. Compared with our previous design, the average bubble size was reduced from 312 to 243 μm, enhancing the enrichment of short-chain PFASs. Using an iron-based metal-organic framework (MIL-101(Fe)) as the assisting material, the method achieved enrichment ratios of 700-fold for PFOS and 400-fold for PFHxS within 30 s. The entire analysis is completed within minutes without organic solvents, offering substantial reductions in time and waste compared with conventional SPE-LC-MS/MS. PFOS concentration of ~3 ng/L was detected in Tamsui River samples, consistent with LC-MS/MS results. This solvent-free, small-bubble-based method provides a sustainable approach for rapid PFAS monitoring in environmental waters.
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