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Tailoring Syringic Acid-Trimesic Acid Mixed-Linker MIL-100(Fe): Evaluation of Drug-Loading Capacity, Bioavailability,
Joshua H Santos1,2, Hannah Jean Victoriano2, Mary Sepulveda2
1Department of Science and Technology-Central Office, General Santos Avenue, Upper Bicutan, Taguig City 1631, Philippines.
Pharmaceutics
|March 28, 2026
Summary
This study developed a novel drug delivery system using modified MIL-100(Fe) with syringic acid, significantly boosting oral bioavailability and demonstrating safety in rats.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmacology
Background:
- Low oral bioavailability of compounds like syringic acid necessitates advanced drug delivery systems.
- MIL-100(Fe) has shown potential as a drug carrier.
- Previous work utilized MIL-100(Fe) for syringic acid encapsulation.
Purpose of the Study:
- To synthesize and characterize a mixed-linker MIL-100(Fe) system incorporating syringic acid.
- To evaluate the in vivo safety and bioavailability of the novel formulation.
- To compare the performance of the modified MIL-100(Fe) with unmodified versions and traditional administration routes.
Main Methods:
- Mixed-linker synthesis of MIL-100(Fe) with syringic acid and trimesic acid.
- Characterization using PXRD, FTIR, BET, SEM, and DLS.
- In vivo acute oral toxicity (OECD 425) and oral bioavailability studies in Sprague Dawley rats.
Main Results:
- Optimized syringic acid incorporation achieved high drug loading (66.85%).
- The SYA@MIL-100(Fe)-10% formulation showed a 5.09-fold increase in oral bioavailability compared to pure syringic acid.
- No adverse effects were observed in toxicity studies; enhanced bioavailability surpassed intraperitoneal administration.
Conclusions:
- Modified MIL-100(Fe) with integrated syringic acid is a safe and effective drug delivery system.
- This novel mixed-linker approach enhances syringic acid's oral bioavailability.
- The study pioneers the use of syringic acid as a structural co-ligand in MIL-100(Fe) synthesis for improved therapeutic outcomes.
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