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Neuroendocrine neoplasm classification: The missing piece of the puzzle
Udhayvir S Grewal1, Calisia N Clarke2, Razelle Kurzrock3
1Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
None:
Neuroendocrine neoplasms (NEN) are heterogenous malignancies classified by morphology, site of origin, and Ki-67 proliferation indices. These complicated classification systems often fail to capture NEN outcome diversity. Molecular profiling advances have revealed distinct genomic portfolios that transcend conventional nosology schema. We highlight current classification limitations and suggest the need for individual molecular tumor portraits as a cornerstone of diagnostic/treatment paradigms.
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