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Reframing clinical trial results: Neutral versus negative outcomes
Elbrich M Postma1, Frédérique T C Hoogsteder1, Bastiaan R Bloem1
1Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Nijmegen, the Netherlands.
Abstract:
Outcomes of clinical trials are traditionally labeled as positive or negative. Labeling of negative trials may have to be refined to better communicate the observed effects. This will distinguish negative trials with neutral outcomes (no difference between intervention and placebo) from trials with worse outcomes (worse outcome in intervention). We illustrate this concept with examples from recent trials.
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