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Metastatic prostate cancer: Clinical trials to watch

Georges Gebrael1, Micah Ostrowski1, Neeraj Agarwal1

  • 1Division of Medical Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

Med (New York, N.Y.)
|November 15, 2025
PubMed

Insights

The treatment for metastatic prostate cancer is changing. Ongoing clinical trials are exploring new strategies and therapies for both hormone-sensitive and castration-resistant prostate cancer.

Area of Science:

  • Oncology
  • Medical Oncology
  • Clinical Trials

Background:

  • The treatment landscape for metastatic prostate cancer is dynamic and rapidly evolving.
  • Current management strategies require continuous updates based on emerging evidence.

Purpose of the Study:

  • To provide an overview of ongoing clinical trials in metastatic prostate cancer.
  • To highlight novel treatment strategies and emerging therapies.
  • To discuss potential shifts in managing hormone-sensitive and castration-resistant disease.

Main Methods:

  • Review of ongoing clinical trials.
  • Analysis of novel escalation and de-escalation strategies.
  • Examination of emerging therapies in different disease settings.

Main Results:

  • Several ongoing clinical trials are poised to significantly impact metastatic prostate cancer management.
  • Novel treatment approaches are being investigated for both hormone-sensitive and castration-resistant metastatic prostate cancer.
  • Emerging therapies show promise in reshaping treatment paradigms.

Conclusions:

  • The future management of metastatic prostate cancer will likely involve refined treatment strategies based on ongoing research.
  • Understanding these evolving treatment landscapes is crucial for oncologists and patients.
  • Clinical trials are essential for advancing care in metastatic prostate cancer.

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