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Updated: Jan 11, 2026
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
MicroRNA biosensors for the detection of intestinal diseases
Asma Vafadar1, Sajad Alavimanesh2, Melika Eghtesadi1
1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:
Intestinal disorders, including colorectal cancer, Crohn's disease, and ulcerative colitis, present considerable health challenges due to their complicated pathogenesis and frequently delayed diagnoses. MicroRNAs (miRNAs), which are small non-coding RNA molecules, play a crucial role in regulating various cellular functions related to intestinal health and disease. Abnormal expression of miRNAs has been associated with the onset and progression of these disorders. In light of the clinical importance of miRNAs in intestinal diseases, there is an increasing interest in creating rapid, sensitive, and cost-effective diagnostic methods. Electrochemical biosensors show significant promise in this field, as they are user-friendly, highly sensitive, and can be continuously integrated into point-of-care conditions. This review examines the potential of miRNA-based electrochemical biosensors for the early detection and monitoring of intestinal diseases. We analyze the role of miRNAs in the pathogenesis of these conditions and highlight recent advancements in the development of electrochemical biosensors for detecting miRNAs in intestinal disorders.
Insights
MicroRNAs (miRNAs) are key in intestinal diseases. Electrochemical biosensors offer a promising, sensitive method for early detection and monitoring of these conditions, improving patient outcomes.
Area of Science:
- Biomedical Engineering
- Molecular Biology
- Gastroenterology
Background:
- Intestinal disorders like colorectal cancer, Crohn's disease, and ulcerative colitis pose significant health challenges due to complex pathogenesis and delayed diagnosis.
- MicroRNAs (miRNAs) are critical regulators of cellular functions involved in intestinal health and disease, with abnormal expression linked to disease onset and progression.
Purpose of the Study:
- To review the potential of miRNA-based electrochemical biosensors for early detection and monitoring of intestinal diseases.
- To analyze the role of miRNAs in the pathogenesis of intestinal disorders.
- To highlight advancements in electrochemical biosensor development for miRNA detection in these conditions.
Main Methods:
- Review of current literature on miRNA roles in intestinal diseases.
- Analysis of recent developments in electrochemical biosensor technology for miRNA detection.
- Examination of the application of these biosensors for point-of-care diagnostics.
Main Results:
- Abnormal miRNA expression is a hallmark of intestinal disorders.
- Electrochemical biosensors offer rapid, sensitive, and user-friendly detection of miRNAs.
- These biosensors show potential for integration into point-of-care settings for continuous monitoring.
Conclusions:
- miRNA-based electrochemical biosensors represent a promising frontier for the early diagnosis and management of intestinal diseases.
- Further advancements in biosensor technology could significantly improve patient outcomes through timely intervention.
- This approach holds potential for personalized medicine in gastroenterology.
