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Related Experiment Video

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Theranostics in surgical oncology.

S Stättner1, Kjetil Soreide2, Julie Hallet3

  • 1Hepatobiliary Center, Department of General and Visceral Surgery, Kepler University Hospital GmbH, Linz, Austria; Johannes Kepler University, Medical Faculty, Linz, Austria.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|November 16, 2025
PubMed
Summary

Theranostics combines tumor-targeting molecules with radioisotopes for cancer detection and treatment. This approach, particularly using somatostatin receptor (SSTR) targeting peptides, offers effective diagnostics and therapy for neuroendocrine tumors (NET).

Keywords:
For submissionNETNeuroendocrine tumorNuclear medicineOncologic surgeryRadiopharmaceutic therapySurgical oncologyTheranostics

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Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiopharmaceutical Therapy

Background:

  • Theranostics couples targeting molecules with radioisotopes for dual diagnostic and therapeutic applications.
  • Somatostatin receptor (SSTR) targeting peptides are crucial for neuroendocrine tumor (NET) theranostics, utilizing isotopes like 68Ga (diagnostic) and 177Lu (therapeutic).

Purpose of the Study:

  • To review current theranostic applications and emerging developments in surgical oncology.
  • To highlight the potential of theranostics in improving tumor detection, guiding surgery, and enhancing treatment efficacy, especially for difficult-to-treat or resistant tumors.

Main Methods:

  • Review of current theranostic strategies utilizing SSTR-targeting peptides.
  • Exploration of novel radiopharmaceuticals, isotopes, and combination therapies in development.
  • Discussion of the role of theranostics in surgical oncology, including neoadjuvant approaches.

Main Results:

  • SSTR-targeted theranostics enable high-sensitivity detection and effective treatment of SSTR-positive NETs.
  • Theranostics can guide surgical interventions and improve tumor resectability.
  • Ongoing research focuses on overcoming resistance and enhancing antitumor effectiveness through new isotopes and combination therapies.

Conclusions:

  • Theranostics, particularly with SSTR-targeting agents, significantly benefits NET management.
  • Expanding theranostic options promises wider accessibility and improved outcomes for more patients globally.
  • Theranostics holds considerable promise for advancing surgical oncology and personalized cancer care.