Damage-associated molecular patterns and coagulation

Damage-associated molecular patterns (DAMPs), released into the extracellular space following tissue injury, are increasingly recognised as potent procoagulant molecules integral to haemostasis and the pathogenesis of thrombosis. Their procoagulant influence spans all phases of the cell-based model of coagulation while simultaneously extending beyond traditional haemostatic pathways through direct modulation of inflammatory and innate immune responses. By coupling coagulation and immunity, DAMPs drive the self-perpetuating cycle of immunothrombosis characteristic of many critical illnesses. Targeting this underexplored interface offers the promise of novel diagnostic and therapeutic approaches, particularly in conditions where coagulopathy coexists with hyperinflammatory states.