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Updated: Apr 30, 2026
06:54
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
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Sparse-view reconstruction and noise reduction in 99m Tc-prostate specific membrane antigen prostate imaging
Sayna Jamaati1, Masoumeh Dorri Giv2, Xiaotong Hong3
1Department of Energy Engineering, Sharif University of Technology, Tehran.
Nuclear Medicine Communications
|November 17, 2025
Summary
Sparse-view 99mTc-PSMA SPECT imaging with 30 views is feasible for prostate cancer. Nonlocal means filtering improved image quality over Gaussian filtering, enhancing diagnostic accuracy in this preliminary study.
Area of Science:
- Nuclear Medicine
- Medical Imaging
- Radiochemistry
Background:
- Prostate-specific membrane antigen (PSMA) targeted imaging is crucial for prostate cancer management.
- Single photon emission computed tomography (SPECT) is a key modality for PSMA imaging.
- Sparse-view acquisition techniques aim to reduce scan times and radiation dose.
Purpose of the Study:
- To evaluate the feasibility and clinical value of sparse-view 99mTc-PSMA SPECT for prostate imaging.
- To compare the performance of traditional Gaussian filtering versus edge-preserving nonlocal means (NLM) filtering in sparse-view SPECT reconstructions.
- To assess the impact of reduced view sampling on image quality and diagnostic accuracy.
Main Methods:
- Ten patients with biopsy-proven prostate cancer underwent full-angle 99mTc-PSMA SPECT acquisitions.
- Data were retrospectively decimated to 30, 15, and 10 views.
- Images were reconstructed using ordered-subsets expectation maximization and postfiltered with Gaussian or NLM filters.
- Quantitative metrics (MAPE, NRMSE, PSNR, NB) and blinded visual assessments by nuclear medicine physicians were performed.
Main Results:
- Halving the views to 30 preserved diagnostic accuracy with minimal error (MAPE_ROI1 ≤ 7%).
- Reconstructions with 15 views showed artifacts due to undersampling; 10 views yielded unacceptable image quality.
- NLM filtering significantly outperformed Gaussian filtering for 30-view reconstructions, improving NRMSE, PSNR, and NB.
- Expert readers showed high interobserver agreement for 30-view reconstructions.
Conclusions:
- Sparse-view 99mTc-PSMA SPECT using 30 views is feasible for routine and emergency prostate imaging.
- Reconstructions from 15 views are not recommended without anti-aliasing strategies due to aliasing artifacts.
- NLM postreconstruction filtering offers added value for sparse-view PSMA-SPECT, warranting further investigation in larger studies.
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