Related Experiment Video
Updated: Jan 11, 2026

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
NPASS database update 2026: comprehensive quantitative composition, bioactivity, and ADME-Tox data of natural
Hanbo Lin1, Dongyue Hou1, Xianhan Jiang1
1School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics, Fudan University, Shanghai 201203, P.R. China.
None:
Bioactive natural products (NPs) are valuable sources for biomedical and various applications. Comprehensive information on their species sources and quantitative properties (including compositions, bioactivities, and toxicities) is of great utility to the research community. Here, we introduced NPASS 3.0 with major updates to significantly expand the previous version and add new data derived from emerging technologies. Firstly, we manually curated new records from 1822 publications to provide: (i) an additional 87 507 quantitative composition records for 4873 NPs in 1030 species and (ii) 878 NPs produced by 341 symbiont organisms and 164 elicitor-responsive organisms, together with an additional 109 engineered organisms and 43 co-culture organisms. Secondly, 34 975 new quantitative toxicity records for 3662 NPs and 9713 quantitative ADME records for 744 NPs. Thirdly, this update substantially increased the records of NPASS, with 9.37%-206.30% data expansion over NPASS 2.0. Currently, NPASS includes 204 023 NPs, 48 940 organisms, 8764 targets, 1 048 756 experimental activity records, 34 975 toxicity records, 9713 quantitative ADME records, 208 415 NP composition records, and 1 117 269 organism-NP pairs. Furthermore, bioactivities were grouped into three classes for better serving pharmaceutical research. We also updated the NPASS web interface, which includes an enhanced search option and a submission page for crowdsourcing curation. NPASS 3.0 is accessible at https://bidd.group/NPASS/index.php.
More Related Videos
05:35An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome
Published on: September 20, 2022
08:20Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Related Concept Videos
Drug Discovery: Overview
Prodrugs
Prodrugs help overcome...
Dosage Regimens: Partial Pharmacokinetic Parameters
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
Analysis of Population Pharmacokinetic Data
Biopharmaceutics and Pharmacokinetics: Overview